Article
Novel, structure-based mechanism for uridylylation of the genome-linked peptide (VPg) of picornaviruses.
Proteins - 1 Jun 2006
Schein Catherine H, Volk David E, Oezguen Numan, Paul Aniko
Abstract excerpt
The VPg peptide, which is found in poliovirus infected cells either covalently bound to the 5'-end of both plus and minus strand viral RNA, or in a uridylylated free form, is essential for picornavirus replication. Combining experimental structure and mutation results with molecular modeling suggests a new mechanism for VPg uridylylation, which assigns an additional function, that of scaffold, to the polymerase....
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