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Article

Allosteric effects of ligands and mutations on poliovirus RNA-dependent RNA polymerase.

Journal of virology - 1 Jun 2005

Boerner Joanna E, Lyle John M, Daijogo Sarah, Semler Bert L, Schultz Stephen C, Kirkegaard Karla, Richards Oliver C

Abstract excerpt

Protein priming of viral RNA synthesis plays an essential role in the replication of picornavirus RNA. Both poliovirus and coxsackievirus encode a small polypeptide, VPg, which serves as a primer for addition of the first nucleotide during synthesis of both positive and negative strands. This study examined the effects on the VPg uridylylation reaction of the RNA template sequence, the origin of VPg...

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Source

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Identifiers

PMID: 15919933
DOI: 10.1128/JVI.79.12.7803-7811.2005
PMCID: PMC1143668

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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