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Article

Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.

Science (New York, N.Y.) - 20 Jan 2006

Goll Mary Grace, Kirpekar Finn, Maggert Keith A, Yoder Jeffrey A, Hsieh Chih-Lin, Zhang Xiaoyu, Golic Kent G, Jacobsen Steven E, Bestor Timothy H

Abstract excerpt

The sequence and the structure of DNA methyltransferase-2 (Dnmt2) bear close affinities to authentic DNA cytosine methyltransferases. A combined genetic and biochemical approach revealed that human DNMT2 did not methylate DNA but instead methylated a small RNA; mass spectrometry showed that this...

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PMID: 16424344
DOI: 10.1126/science.1120976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16424344-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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