Article
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
Science (New York, N.Y.) - 20 Jan 2006
Goll Mary Grace, Kirpekar Finn, Maggert Keith A, Yoder Jeffrey A, Hsieh Chih-Lin, Zhang Xiaoyu, Golic Kent G, Jacobsen Steven E, Bestor Timothy H
Abstract excerpt
The sequence and the structure of DNA methyltransferase-2 (Dnmt2) bear close affinities to authentic DNA cytosine methyltransferases. A combined genetic and biochemical approach revealed that human DNMT2 did not methylate DNA but instead methylated a small RNA; mass spectrometry showed that this RNA is aspartic acid transfer RNA (tRNA(Asp)) and that DNMT2 specifically methylated cytosine 38 in the anticodon loop....
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