Article
The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.
Nucleic acids research - 21 Jun 2021
Ramos-Morales Elizabeth, Bayam Efil, Del-Pozo-Rodríguez Jordi, Salinas-Giegé Thalia, Marek Martin, Tilly Peggy, Wolff Philippe, Troesch Edouard, Ennifar Eric, Drouard Laurence, Godin Juliette D, Romier Christophe
Abstract excerpt
Post-transcriptional modification of tRNA wobble adenosine into inosine is crucial for decoding multiple mRNA codons by a single tRNA. The eukaryotic wobble adenosine-to-inosine modification is catalysed by the ADAT (ADAT2/ADAT3) complex that modifies up to eight tRNAs, requiring a full tRNA for activity. Yet, ADAT catalytic mechanism and its implication in neurodevelopmental disorders remain poorly understood....
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