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Article

Association of functionally different RUNX2 P2 promoter alleles with BMD.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2006

Doecke James D, Day Christopher J, Stephens Alexandre S J, Carter Shea L, van Daal Angela, Kotowicz Mark A, Nicholson Geoff C, Morrison Nigel A

Abstract excerpt

UNLABELLED: RUNX2 gene SNPs were genotyped in subjects from the upper and lower deciles of age- and weight-adjusted femoral neck BMD. Of 16 SNPs in RUNX2 and its two promoters (P1 and P2), only SNPs in the P2 promoter were significantly associated with BMD. These P2 promoter SNPs were functionally different in gel-shift and promoter activity assays. INTRODUCTION: Specific osteoblast genes are induced by Runx2, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16418782
DOI: 10.1359/JBMR.051013

Genes

RUNX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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