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Article

Genetic analysis identifies DDR2 as a novel gene affecting bone mineral density and osteoporotic fractures in Chinese population.

PloS one - 1 Jan 2015

Guo Yan, Yang Tie-Lin, Dong Shan-Shan, Yan Han, Hao Ruo-Han, Chen Xiao-Feng, Chen Jia-Bin, Tian Qing, Li Jian, Shen Hui, Deng Hong-Wen

Abstract excerpt

DDR2 gene, playing an essential role in regulating osteoblast differentiation and chondrocyte maturation, may influence bone mineral density (BMD) and osteoporosis, but the genetic variations actually leading to the association remain to be elucidated. Therefore, the aim of this study was to investigate whether the genetic variants in DDR2 are associated with BMD and fracture risk. This study was performed in...

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Identifiers

PMID: 25658585
DOI: 10.1371/journal.pone.0117102
PMCID: PMC4319719

Genes

DDR2

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