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Article

Promoter 2 -1025 T/C polymorphism in the RUNX2 gene is associated with femoral neck bmd in Spanish postmenopausal women.

Calcified tissue international - 1 Oct 2007

Bustamante Mariona, Nogués Xavier, Agueda Lídia, Jurado Susana, Wesselius Anke, Cáceres Enrique, Carreras Ramon, Ciria Manel, Mellibovsky Leonardo, Balcells Susana, Díez-Pérez Adolfo, Grinberg Daniel

Abstract excerpt

Stimulation of bone formation is a key therapeutic target in osteoporosis. Runx2 is a runt domain transcription factor essential to osteoblast differentiation, bone remodeling, and fracture healing. Runx2 knockout mice exhibit a complete lack of ossification, while overexpression of this gene in...

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Source

Identifiers

PMID: 17878995
DOI: 10.1007/s00223-007-9069-2

Genes

RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17878995-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Promoter 2 -1025 T/C polymorphism in the RUNX2 gene is associated with femoral neck bmd in Spanish postmenopausal women.PMID 17878995Read ↗

Association of a RUNX2 promoter polymorphism with bone mineral density in postmenopausal Korean women.Semantic proximity Read ↗

Common polymorphisms rather than rare genetic variants of the Runx2 gene are associated with femoral neck BMD in Spanish women.Semantic proximity Read ↗

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The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation.Semantic proximity Read ↗

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