Article
Association of a RUNX2 promoter polymorphism with bone mineral density in postmenopausal Korean women.
Calcified tissue international - 1 Jun 2009
Lee Hee-Jung, Koh Jung-Min, Hwang Joo-Yeon, Choi Kang-Yell, Lee Seung Hun, Park Eui Kyun, Kim Tae-Ho, Han Bok Ghee, Kim Ghi Su, Kim Shin-Yoon, Lee Jong-Young
Abstract excerpt
Osteoporosis is characterized by impaired osteoblastogenesis. Bone mineral density (BMD) is a major determinant of bone strength. RUNX2 is an osteoblast-specific transcription factor involved in osteoblast differentiation and ossification. To determine whether RUNX2 is associated with BMD in an ethnically distinct population, we investigated SNPs within the two RUNX2 promoters (P1 and P2) using the Illuminar...
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