Article
Label-free detection of DNA hybridization using carbon nanotube network field-effect transistors.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jan 2006
Star Alexander, Tu Eugene, Niemann Joseph, Gabriel Jean-Christophe P, Joiner C Steve, Valcke Christian
Abstract excerpt
We report carbon nanotube network field-effect transistors (NTNFETs) that function as selective detectors of DNA immobilization and hybridization. NTNFETs with immobilized synthetic oligonucleotides have been shown to specifically recognize target DNA sequences, including H63D single-nucleotide polymorphism (SNP) discrimination in the HFE gene, responsible for hereditary hemochromatosis. The electronic responses...
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