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Article

Potentiometric Detection of Single Nucleotide Polymorphism by Using a Genetic Field-effect transistor.

Chembiochem : a European journal of chemical biology - 1 Apr 2005

Sakata Toshiya, Miyahara Yuji

Abstract excerpt

Potentiometric measurement of allele-specific oligonucleotide hybridization based on the principle of detection of charge-density change at the surface of a gate insulator by using of a genetic field-effect transistor has been demonstrated. Since DNA molecules are negatively charged in aqueous solution, a hybridization event at the gate surface leads to a charge-density change in the channel of the FET and can be...

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PMID: 15812785
DOI: 10.1002/cbic.200400253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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