Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor.

doi:10.1038/s41551-021-00706-z

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Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor.

Nature biomedical engineering - 1 Jul 2021

Balderston Sarah, Taulbee Jeffrey J, Celaya Elizabeth, Fung Kandace, Jiao Amanda, Smith Kasey, Hajian Reza, Gasiunas Giedrius, Kutanovas Simonas, Kim Daehwan, Parkinson Jonathan, Dickerson Kenneth, Ripoll Juan-José, Peytavi Regis, Lu Hsiang-Wei, Barron Francie, Goldsmith Brett R, Collins Philip G, Conboy Irina M, Siksnys Virginijus, Aran Kiana

Abstract excerpt

Simple and fast methods for the detection of target genes with single-nucleotide specificity could open up genetic research and diagnostics beyond laboratory settings. We recently reported a biosensor for the electronic detection of unamplified target genes using liquid-gated graphene field-effect transistors employing an RNA-guided catalytically deactivated CRISPR-associated protein 9 (Cas9) anchored to a...

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PMID: 33820980
DOI: 10.1038/s41551-021-00706-z

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