Article
Electronic detection of nucleic acids: a versatile platform for molecular diagnostics.
The Journal of molecular diagnostics : JMD - 1 May 2001
Umek R M, Lin S W, Vielmetter J, Terbrueggen R H, Irvine B, Yu C J, Kayyem J F, Yowanto H, Blackburn G F, Farkas D H, Chen Y P
Abstract excerpt
A novel platform for the electronic detection of nucleic acids on microarrays is introduced and shown to perform well as a selective detection system for applications in molecular diagnostics. A gold electrode in a printed circuit board is coated with a self-assembled monolayer (SAM) containing DNA capture probes. Unlabeled nucleic acid targets are immobilized on the surface of the SAM through sequence-specific...
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