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Article

Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes.

The Journal of clinical investigation - 15 Nov 1997

Ray P, Tang W, Wang P, Homer R, Kuhn C, Flavell R A, Elias J A

Abstract excerpt

Standard overexpression transgenic approaches are limited in their ability to model waxing and waning diseases and frequently superimpose development-dependent and -independent phenotypic manifestations. We used the clara cell 10-kD protein (CC10) promoter and the reverse tetracycline transactivator (rtTA) to create a lung-specific, externally regulatable, overexpression transgenic system and used this system to...

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Identifiers

PMID: 9366564
DOI: 10.1172/JCI119792
PMCID: PMC508450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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