Article
Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis.
Thrombosis and haemostasis - 1 Dec 2019
Horowitz Jeffrey C, Tschumperlin Daniel J, Kim Kevin K, Osterholzer John J, Subbotina Natalya, Ajayi Iyabode O, Teitz-Tennenbaum Seagal, Virk Ammara, Dotson Megan, Liu Fei, Sicard Delphine, Jia Shijing, Sisson Thomas H
Abstract excerpt
INTRODUCTION: Impaired plasminogen activation (PA) is causally related to the development of lung fibrosis. Prior studies demonstrate that enhanced PA in the lung limits the severity of scarring following injury and in vitro studies indicate that PA promotes matrix degradation and fibroblast apoptosis. These findings led us to hypothesize that increased PA in an in vivo model would enhance the resolution of...
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