Article
Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jan 2006
Guzowski John F, Miyashita Teiko, Chawla Monica K, Sanderson Jennifer, Maes Levi I, Houston Frank P, Lipa Peter, McNaughton Bruce L, Worley Paul F, Barnes Carol A
Abstract excerpt
The ability of neurons to alter their transcriptional programs in response to synaptic input is of fundamental importance to the neuroplastic mechanisms underlying learning and memory. Because of technical limitations of conventional gene detection methods, the current view of activity-dependent neural transcription derives from experiments in which neurons are assumed quiescent until a signaling stimulus is...
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