Epigenetic Control of Adaptive or Homeostatic Splicing of Alternative Exons and <i>Prolactin</i> Gene Expression During Interval-Training Activities of Pituitary Cells

Abstract excerpt

Interval-training activities induce adaptive cellular changes without altering their fundamental identity, but the precise underlying molecular mechanisms are not fully understood. In this study, we demonstrate that interval-training depolarization (ITD) of pituitary cells triggers distinct adaptive or homeostatic splicing responses of alternative exons. This occurs while preserving the steady-state expression of...

Topics

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• Animals, Newborn
• Arginine Vasopressin
• Behavior, Animal
• Corticosterone
• Depression
• Enhancer Elements, Genetic
• Hypothalamo-Hypophyseal System
• Methyl-CpG-Binding Protein 2

Identifiers and source

Literature Corpus work

29f44606-f5dd-50c7-b641-811e02758db4

DOI

10.1101/2024.02.23.581772