Article

Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

2021-09-20

Abstract excerpt

Fragile X syndrome (FXS) is a common single gene cause of intellectual disability and Autism Spectrum Disorder. Cognitive inflexibility is one of the hallmarks of FXS with affected individuals showing extreme difficulty adapting to novel or complex situations. To explore the neural correlates of this cognitive inflexibility, we used a rat model of FXS ( Fmr1 -/y ), and recorded from the CA1 region of the hippocam...

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Literature Corpus work: 3c1c62dc-dac2-5f68-92e4-8747862f0aaa
DOI: 10.1101/2021.09.17.460768

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