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Article

Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates.

Journal of virology - 1 Feb 2001

Foster J L, Molina R P, Luo T, Arora V K, Huang Y, Ho D D, Garcia J V

Abstract excerpt

We have characterized the functional integrity of seven primary Nef isolates: five from a long-term nonprogressing human immunodeficiency virus (HIV)-infected individual and one each from two patients with AIDS. One of the seven Nefs was defective for CD4 downregulation, two others were defective for PAK-2 activation, and one Nef was defective for PAK-2 activation and major histocompatibility complex (MHC) class...

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Source

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Identifiers

PMID: 11160665
DOI: 10.1128/JVI.75.4.1672-1680.2001
PMCID: PMC114076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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