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Article

A novel polymorphism in SEL1L confers susceptibility to Alzheimer's disease.

Neuroscience letters - 1 May 2006

Saltini Giuliana, Dominici Roberto, Lovati Carlo, Cattaneo Monica, Michelini Stefania, Malferrari Giulia, Caprera Andrea, Milanesi Luciano, Finazzi Dario, Bertora Pierluigi, Scarpini Elio, Galimberti Daniela, Venturelli Eliana, Musicco Massimo, Adorni Fulvio, Mariani Claudio, Biunno Ida

Abstract excerpt

Alzheimer's disease (AD) is considered to be a conformational disease arising from the accumulation of misfolded and unfolded proteins in the endoplasmic reticulum (ER). SEL1L is a component of the ER stress degradation system, which serves to remove unfolded proteins by retrograde degradation using the ubiquitin-proteosome system. In order to identify genetic variations possibly involved in the disease, we...

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PMID: 16412574
DOI: 10.1016/j.neulet.2005.12.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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