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Article

DNA sequence analysis of the conserved region around the SOD1 gene locus in recessively inherited ALS.

Neuroscience letters - 29 Sept 2009

Broom Wendy J, Johnson Daniel V, Garber Manuel, Andersen Peter M, Lennon Niall, Landers John, Nusbaum Chad, Russ Carsten, Brown Robert H

Abstract excerpt

Familial amyotrophic lateral sclerosis (ALS) accounts for 10% of all ALS cases; 12-23% are associated with mutations in the Cu/Zn superoxide dismutase gene (SOD1). All ALS-linked SOD1 mutations present with a dominant pattern of inheritance apart from the aspartate to alanine mutation in exon 4 (D90A). This mutation has been observed in dominant, recessive and apparently sporadically cases. SOD1(D90A/D90A) ALS...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19596401
DOI: 10.1016/j.neulet.2009.07.010

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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