Article
Paraoxonase 1 gene polymorphisms influence clinical features of open-angle glaucoma.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Aug 2006
Inagaki Yoko, Mashima Yukihiko, Funayama Tomoyo, Ohtake Yuichiro, Fuse Nobuo, Yasuda Noriko, Fukuchi Takeo, Murakami Akira, Hotta Yoshihiro
Abstract excerpt
BACKGROUND: The purpose of this study was to determine whether genetic polymorphisms affecting high-density lipoprotein (HDL)-associated antioxidant enzymes were associated with open-angle glaucoma (OAG). The rationale for this study was that the modification of low-density lipoprotein (LDL) by HDL prevents oxidative modification which can then cause dysfunction of endothelial cells. METHODS: We studied 284...
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