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Article

An AU at the first base pair of helix 3 elevates the catalytic activity of hepatitis delta virus ribozymes.

FEBS letters - 18 Aug 1997

Huang Z S, Ping Y H, Wu H N

Abstract excerpt

A mutational analysis of the helix 3 (H3) region of hepatitis delta virus (HDV) ribozymes disclosed that an AU at the first base pair of H3 elevates the catalytic activity of various cis- and trans-acting HDV ribozymes. A GC to AU substitution at this position of H3, which is located at the junct...

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Source

Identifiers

PMID: 9280301
DOI: 10.1016/s0014-5793(97)00902-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9280301-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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An AU at the first base pair of helix 3 elevates the catalytic activity of hepatitis delta virus ribozymes.PMID 9280301Read ↗

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Formation of the P1.1 pseudoknot is critical for both the cleavage activity and substrate specificity of an antigenomic trans-acting hepatitis delta ribozyme.Semantic proximity Read ↗

Detailed analysis of base preferences at the cleavage site of a trans-acting HDV ribozyme: a mutation that changes cleavage site specificity.Semantic proximity Read ↗

Design of a highly reactive HDV ribozyme sequence uncovers facilitation of RNA folding by alternative pairings and physiological ionic strength.Semantic proximity Read ↗

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