Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling.

doi:10.1523/JNEUROSCI.3221-05.2006

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Article

Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Jan 2006

Wang Yanshu, Zhang Jiangyang, Mori Susumu, Nathans Jeremy

Abstract excerpt

Previous work has identified axonal outgrowth and/or guidance defects in the brain and spinal cord of prenatal Frizzled3 (Fz3)(-/-) mice. To systematically explore the axonal defects in Fz3(-/-) mice and to compare techniques for the global assessment of axon tracts in the developing mouse, we have analyzed wild-type and Fz3(-/-) brains using (1) diffusion tensor magnetic resonance imaging (muDTI), (2)...

Topics

Abnormalities, Multiple
Alkaline Phosphatase
Animals
Axons
Bacterial Proteins
Brain
Diffusion Magnetic Resonance Imaging
Frizzled Receptors
GPI-Linked Proteins
Genes, Lethal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Reporter

Integrases

Intermediate Filaments

Isoenzymes

Luminescent Proteins

Mice

Mice, Knockout

Mice, Transgenic

Source

Open in PubMed Open full text

Identifiers

PMID: 16407530
DOI: 10.1523/JNEUROSCI.3221-05.2006
PMCID: PMC6674392

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