WDFY3 mutation alters laminar position and morphology of cortical neurons.

doi:10.1186/s13229-022-00508-3

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Article

WDFY3 mutation alters laminar position and morphology of cortical neurons.

Molecular autism - 22 Jun 2022

Schaaf Zachary A, Tat Lyvin, Cannizzaro Noemi, Panoutsopoulos Alexios A, Green Ralph, Rülicke Thomas, Hippenmeyer Simon, Zarbalis Konstantinos S

Abstract excerpt

BACKGROUND: Proper cerebral cortical development depends on the tightly orchestrated migration of newly born neurons from the inner ventricular and subventricular zones to the outer cortical plate. Any disturbance in this process during prenatal stages may lead to neuronal migration disorders (NMDs), which can vary in extent from focal to global. Furthermore, NMDs show a substantial comorbidity with other...

Topics

Adaptor Proteins, Signal Transducing
Animals
Autistic Disorder
Autophagy-Related Proteins
Cerebral Cortex
Humans
Mice
Mutation
Neurogenesis
Neurons

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Identifiers

PMID: 35733184
DOI: 10.1186/s13229-022-00508-3
PMCID: PMC9219247

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