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Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging

5 Jan 2006

Abstract excerpt

Diffusion tensor magnetic resonance imaging (DT-MRI) was applied for in vivo quantification of myelin loss and regeneration. A transgenic mouse line (Oligo-TTK) expressing a truncated form of the herpes simplex virus 1 thymidine kinase gene (hsv1-tk) in oligodendrocytes was studied along with two induced phenotypes of myelin pathology. Myelin loss and axonal abnormalities differentially affect values of DT-MRI...

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PMID: 16397901
DOI: 10.1002/jnr.20742

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