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Article

p53 in chronic myeloid leukemia cell lines.

Leukemia - 1 Aug 1992

Bi S, Hughes T, Bungey J, Chase A, de Fabritiis P, Goldman J M

Abstract excerpt

Four human chronic myeloid leukemia (CML) cell lines, BV173, K562, KCL-22, and KYO-1, were studied for inactivation of human tumor suppressor gene p53. Southern blotting showed allele deletion in KCL-22 and cytogenetic studies showed a chromosome 17 deletion in KYO-1 but no gross structural abnormalities in the other two lines. Northern blotting showed increased amounts of normal size p53 mRNA in BV-173 and...

Topics

Base Sequence
Blast Crisis
Blotting, Northern
Blotting, Southern
Gene Expression
Genes, p53
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 1640738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1640738-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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