Article
Mutational inactivation of the p53 gene in the human erythroid leukemic K562 cell line.
Leukemia research - 1 Dec 1993
Law J C, Ritke M K, Yalowich J C, Leder G H, Ferrell R E
Abstract excerpt
The K562 human chronic myelogenous leukemia (CML) cell line has attained widespread use as a model for studying hematologic malignancy and erythroid differentiation. Sequencing of the p53 gene in the K562 cell line demonstrated a mutation in exon 5 characterized by a single base insertion (cytosine) between codons 135 and 136. This frameshift mutation leads to an N-terminal truncated protein of 147 amino acids....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.