Article
Mutational inactivation of the p53 gene in the human erythroid leukemic K562 cell line.
Leukemia research - 1 Dec 1993
Law J C, Ritke M K, Yalowich J C, Leder G H, Ferrell R E
Abstract excerpt
The K562 human chronic myelogenous leukemia (CML) cell line has attained widespread use as a model for studying hematologic malignancy and erythroid differentiation. Sequencing of the p53 gene in the K562 cell line demonstrated a mutation in exon 5 characterized by a single base insertion (cytosi...
Topics
- Amino Acid Sequence
- Base Sequence
- Blotting, Western
- Cell Line
- Codon
- Cytosine
- DNA Primers
- DNA Transposable Elements
- DNA, Neoplasm
- Exons
- Genes, p53
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53