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Article

IL-10 deficiency leads to somatic mutations in a model of IBD.

Carcinogenesis - 1 May 2006

Sato Yuichirou, Takahashi Seiichi, Kinouchi Yoshitaka, Shiraki Manabu, Endo Katsuya, Matsumura Yoshifumi, Kakuta Yoichi, Tosa Masaki, Motida Atsuhiro, Abe Hiroko, Imai Go, Yokoyama Hiroshi, Nomura Eiki, Negoro Kenichi, Takagi Sho, Aihara Hiroyuki, Masumura Ken-ichi, Nohmi Takehiko, Shimosegawa Tooru

Abstract excerpt

Individuals with inflammatory bowel disease (IBD) are at increased risk of developing gastrointestinal cancer. Here, we have tested the possibility that chronic inflammation could trigger mutations. For this, we have used IL-10-deficient (IL-10-/-) mice, which spontaneously develop intestinal inf...

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Identifiers

PMID: 16407368
DOI: 10.1093/carcin/bgi327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16407368-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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