Article
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice.
The Journal of clinical investigation - 1 Jul 2008
Meira Lisiane B, Bugni James M, Green Stephanie L, Lee Chung-Wei, Pang Bo, Borenshtein Diana, Rickman Barry H, Rogers Arlin B, Moroski-Erkul Catherine A, McFaline Jose L, Schauer David B, Dedon Peter C, Fox James G, Samson Leona D
Abstract excerpt
Chronic inflammation increases cancer risk. While it is clear that cell signaling elicited by inflammatory cytokines promotes tumor development, the impact of DNA damage production resulting from inflammation-associated reactive oxygen and nitrogen species (RONS) on tumor development has not been directly tested. RONS induce DNA damage that can be recognized by alkyladenine DNA glycosylase (Aag) to initiate base...
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