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Article

A developmental switch in B lymphopoiesis.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1991

Hardy R R, Hayakawa K

Abstract excerpt

B and T lymphocytes are generated from hematopoietic stem cells during both fetal and adult life. A critical unresolved issue is whether the differentiation pathways in lymphopoiesis are the same in fetal and adult animals or whether they differ, similar to the hemoglobin switch in erythropoiesis. We report here that a developmental switch occurs in B lymphopoiesis. We isolated "pro-B" cells (i.e., cells that...

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Identifiers

PMID: 1722338
DOI: 10.1073/pnas.88.24.11550
PMCID: PMC53173

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