Article
A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2003
Ara Toshiaki, Itoi Manami, Kawabata Kenji, Egawa Takeshi, Tokoyoda Koji, Sugiyama Tatsuki, Fujii Nobutaka, Amagai Takashi, Nagasawa Takashi
Abstract excerpt
The functions of a chemokine CXC chemokine ligand (CXCL) 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its physiologic receptor CXCR4 in T cell development are controversial. In this study, we have genetically further characterized their roles in fetal and adult T cell development using mutant and chimeric mice. In CXCL12(-/-) or CXCR4(-/-) embryos on a C57BL/6 background, accumulation...
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