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Article

Influence of phenotype and pharmacokinetics on beta-blocker drug target pharmacogenetics.

The pharmacogenomics journal - 1 Jan 2000

Beitelshees A L, Zineh I, Yarandi H N, Pauly D F, Johnson J A

Abstract excerpt

Two common polymorphisms in the beta1-adrenergic receptor gene, Ser49Gly and Arg389Gly, are associated with variable antihypertensive response to metoprolol. We sought to determine whether similar pharmacogenetic associations were present with the negative chronotropic response phenotype to metoprolol. Metoprolol was titrated in 54 untreated hypertensive patients to achieve blood pressure control. We found no...

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Identifiers

PMID: 16402084
DOI: 10.1038/sj.tpj.6500354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Influence of phenotype and pharmacokinetics on beta-blocker drug target pharmacogenetics.PMID 16402084Read ↗

Genetic polymorphisms of beta1 adrenergic receptor and their influence on the cardiovascular responses to metoprolol in a South Indian population.Semantic proximity Read ↗

Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol.Semantic proximity Read ↗

A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade.Semantic proximity Read ↗

Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol.Semantic proximity Read ↗

beta-Adrenergic receptor polymorphisms and responses during titration of metoprolol controlled release/extended release in heart failure.Semantic proximity Read ↗

Beta1-adrenergic receptor gene polymorphisms and response to beta1-adrenergic receptor blockade in patients with essential hypertension.Semantic proximity Read ↗

Ser49Gly of beta1-adrenergic receptor is associated with effective beta-blocker dose in dilated cardiomyopathy.Semantic proximity Read ↗

Impact of β(1)- and β(2)-adrenergic receptor gene single nucleotide polymorphisms on heart rate response to metoprolol prior to coronary computed tomographic angiography.Semantic proximity Read ↗

The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity.Semantic proximity Read ↗

An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study.Semantic proximity Read ↗

Impact of the β1-adrenoceptor Arg389Gly polymorphism on heart-rate responses to bisoprolol and carvedilol in heart-failure patients.Semantic proximity Read ↗

The gain-of-function G389R variant of the beta1-adrenoceptor does not influence blood pressure or heart rate response to beta-blockade in hypertensive subjects.Semantic proximity Read ↗

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