Article
Ser49Gly of beta1-adrenergic receptor is associated with effective beta-blocker dose in dilated cardiomyopathy.
Clinical pharmacology and therapeutics - 1 Sept 2005
Magnusson Yvonne, Levin Malin C, Eggertsen Robert, Nyström Ernst, Mobini Reza, Schaufelberger Maria, Andersson Bert
Abstract excerpt
OBJECTIVE: Our objective was to evaluate the influence of polymorphisms at codons 49 and 389 of the beta1-adrenergic receptor (beta1-AR) on the response to beta-blockers and outcome in patients with dilated cardiomyopathy. METHODS: We genotyped both codons of the beta1-AR in 375 patients with dilated cardiomyopathy and 492 control subjects. RESULTS: Neither of the polymorphisms was associated with susceptibility...
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