Article
Genetic polymorphisms of beta1 adrenergic receptor and their influence on the cardiovascular responses to metoprolol in a South Indian population.
Journal of cardiovascular pharmacology - 1 Nov 2008
Mahesh Kumar Koratagere Nagaraju, Ramu Periasamy, Rajan Subramanian, Shewade Deepak Gopal, Balachander Jayaraman, Adithan Chandrasekaran
Abstract excerpt
BACKGROUND AND OBJECTIVE: Beta-blockers show interindividual and interethnic variability in their response. Such variability might be due to the polymorphic variations in the beta1 adrenergic receptor genes viz, Ser49Gly and Arg389Gly. The study evaluated the influence of Ser49Gly and Arg389Gly polymorphisms on the cardiovascular responses to metoprolol in a South Indian population. MATERIALS AND METHODS:...
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