Article
The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity.
Journal of the American College of Cardiology - 6 Dec 2005
Bruck Heike, Leineweber Kirsten, Temme Thomas, Weber Melanie, Heusch Gerd, Philipp Thomas, Brodde Otto-Erich
Abstract excerpt
OBJECTIVES: The purpose of this research was to find out whether, in humans, dobutamine-induced hemodynamic effects and increase in plasma-renin activity (PRA) might be beta1-adrenoceptor (beta1AR) genotype-dependent. BACKGROUND: In vitro Arg389Gly-beta1AR polymorphism exhibits decreased receptor signaling. METHODS: We studied 10 male homozygous Arg389-beta1AR subjects and 8 male homozygous Gly389beta1AR...
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