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Article

Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus involution independently of the Fas/Fas ligand signaling pathway.

International immunopharmacology - 1 Feb 2006

Nagai Haruko, Kubo Masato, Abe Ryo, Yamamoto Masayuki, Nohara Keiko

Abstract excerpt

Thymus involution is one of the most prominent consequences of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The characteristic features of TCDD-induced thymic changes include reductions in the number of the thymocytes and in the ratio of CD4 to CD8 T cells in the thymus. While these changes have been shown to be caused by activation of a transcription factor, the aryl hydrocarbon receptor (AhR), the...

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PMID: 16399633
DOI: 10.1016/j.intimp.2005.08.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus involution independently of the Fas/Fas ligand signaling pathway.PMID 16399633Read ↗

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