Article
Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 2009
Altuwaijri Saleh, Chuang Kuang-Hsiang, Lai Kuo-Pao, Lai Jiann-Jyh, Lin Hung-Yun, Young Faith M, Bottaro Andrea, Tsai Meng-Yin, Zeng Wei-Ping, Chang Hong-Chiang, Yeh Shuyuan, Chang Chawnshang
Abstract excerpt
Estrogens have been linked to a higher female incidence of autoimmune diseases. The role of androgen and the androgen receptor (AR) in autoimmune diseases, however, remains unclear. Here we report that the lack of AR in B cells in different strains of mice, namely general AR knockout, B cell-specific AR knockout, and naturally occurring testicular feminization mutation AR-mutant mice, as well as castrated...
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