Article
Role of Fas apoptosis and MHC genes in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity of T cells.
Toxicology - 17 Jun 1996
Rhile M J, Nagarkatti M, Nagarkatti P S
Abstract excerpt
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is well known for its immunotoxic effects particularly on the thymus as well as on T and B lymphocyte functions. Previous studies have suggested that TCDD may induce apoptosis in thymocytes although its demonstration in vivo has met with limited success....
Topics
- Administration, Oral
- Animals
- Apoptosis
- Cell Division
- Female
- Flow Cytometry
- Fluorescein-5-isothiocyanate
- Gene Expression Regulation
- Homozygote
- Lymph Nodes
- Lymphocyte Activation
- Major Histocompatibility Complex
- Mice
- Mice, Inbred C57BL
- Mitogens
- Mutation
- Polychlorinated Dibenzodioxins
- Receptors, Antigen, T-Cell