Article
Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1998
Staples J E, Murante F G, Fiore N C, Gasiewicz T A, Silverstone A E
Abstract excerpt
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related congeners affect the immune system, causing immunosuppression and thymic atrophy in a variety of animal species. TCDD is believed to exert its effects primarily through the ligand-activated transcription factor, the aryl hydrocarbon receptor...
Topics
- Animals
- Atrophy
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cytochrome P-450 CYP1A1
- Hematopoiesis
- Hyaluronan Receptors
- Immunosuppressive Agents
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype
- Polychlorinated Dibenzodioxins
- Radiation Chimera
- Receptors, Aryl Hydrocarbon
- Receptors, Interleukin-2
- T-Lymphocyte Subsets
- Thymus Gland