Characterization of phenotypic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocytes in vivo and its effect on apoptosis.

doi:10.1006/taap.1998.8390

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Article

Characterization of phenotypic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocytes in vivo and its effect on apoptosis.

Toxicology and applied pharmacology - 1 May 1998

Kamath A B, Nagarkatti P S, Nagarkatti M

Abstract excerpt

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly toxic environmental pollutant and is well known for inducing thymic atrophy in mice, although the exact mechanism of its action remains unclear. Recent studies from our laboratory demonstrated that TCDD induces apoptosis in thymocytes and tha...

Topics

Animals
Antigens, Surface
Apoptosis
Biomarkers
Female
Flow Cytometry
Mice
Mice, Inbred C57BL
Phenotype
Polychlorinated Dibenzodioxins
T-Lymphocytes
Thymus Gland
Time Factors

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