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2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Sept 2002

Laiosa Michael D, Lai Zhi-Wei, Thurmond T Scott, Fiore Nancy C, DeRossi Charles, Holdener Bernadette C, Gasiewicz Thomas A, Silverstone Allen E

Abstract excerpt

It is well established that dioxins cause a variety of toxic effects and syndromes including alterations of lymphocyte development. Exposure to the prototypical dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to severe thymic atrophy in all species studied. It has been shown that most of this toxicity is due to TCDD binding to and activating the aryl hydrocarbon receptor (AHR). Upon activation, the AHR...

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Identifiers

PMID: 12215665
DOI: 10.1093/toxsci/69.1.117

Genes

ARNT2
AHR
ARNT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2.PMID 12215665Read ↗

Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells.Semantic proximity Read ↗

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