Article
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2006
Lee Jong Woo, Soung Young Hwa, Seo Si Hyung, Kim Su Young, Park Cho Hyun, Wang Young Pil, Park Kyeongmee, Nam Suk Woo, Park Won Sang, Kim Sang Ho, Lee Jung Young, Yoo Nam Jin, Lee Sug Hyung
Abstract excerpt
PURPOSE: Recent reports revealed that the kinase domain of the ERBB2 gene is somatically mutated in lung adenocarcinoma, suggesting the mutated ERBB2 gene as an oncogene in human cancers. However, because previous reports focused the mutational search of ERBB2 primarily on lung cancers, the data on ERBB2 mutations in other types of human cancers have been largely unknown. EXPERIMENTAL DESIGN: Here, we did a...
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