Article
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.
Cancer research - 1 Mar 2005
Shigematsu Hisayuki, Takahashi Takao, Nomura Masaharu, Majmudar Kuntal, Suzuki Makoto, Lee Huei, Wistuba Ignacio I, Fong Kwun M, Toyooka Shinichi, Shimizu Nobuyoshi, Fujisawa Takehiko, Minna John D, Gazdar Adi F
Abstract excerpt
Mutations in the epidermal growth factor receptor gene (EGFR) in lung cancers predict for sensitivity to EGFR kinase inhibitors. HER2 (also known as NEU, EGFR2, or ERBB2) is a member of the EGFR family of receptor tyrosine kinases and plays important roles in the pathogenesis of certain human cancers, and mutations have recently been reported in lung cancers. We sequenced the tyrosine kinase domain of HER2 in 671...
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