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Article

Mutations in the Kinase Domain of the HER2/ERBB2 Gene Identified in a Wide Variety of Human Cancers.

The Journal of molecular diagnostics : JMD - 1 Sept 2015

Wen Wenhsiang, Chen Wangjuh Sting, Xiao Nick, Bender Ryan, Ghazalpour Anatole, Tan Zheng, Swensen Jeffrey, Millis Sherri Z, Basu Gargi, Gatalica Zoran, Press Michael F

Abstract excerpt

The HER2 (official name ERBB2) gene encodes a membrane receptor in the epidermal growth factor receptor family amplified and overexpressed in adenocarcinoma. Activating mutations also occur in several cancers. We report mutation analyses of the HER2 kinase domain in 7497 histologically diverse cancers. Forty-five genes, including the kinase domain of HER2 with HER2 IHC and dual in situ hybridization, were...

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Identifiers

PMID: 26320869
DOI: 10.1016/j.jmoldx.2015.04.003
PMCID: PMC6136063

Genes

ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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