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Article

Somatic mutations of the ERBB4 kinase domain in human cancers.

International journal of cancer - 15 Mar 2006

Soung Young Hwa, Lee Jong Woo, Kim Su Young, Wang Young Pil, Jo Keon Hyun, Moon Seok Whan, Park Won Sang, Nam Suk Woo, Lee Jung Young, Yoo Nam Jin, Lee Sug Hyung

Abstract excerpt

The EGFR family consists of 4 receptor tyrosine kinases, EGFR (ERBB1), ERBB2 (HER2), ERBB3 (HER3) and ERBB4 (HER4). Recent reports revealed that the kinase domains of both EGFR (ERBB1) and ERBB2 gene were somatically mutated in human cancers, raising the possibility that the other ERBB members possess somatic mutations in human cancers. Here, we performed mutational analysis of the ERBB4 kinase domain by...

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Topics

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Share to DNA Mutational Analysis
Share to ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Neoplasms

Share to Polymorphism, Single-Stranded Conformational

Share to Protein-Tyrosine Kinases

Share to Receptor, ErbB-4

Share to Sequence Deletion

Source

Identifiers

PMID: 16187281
DOI: 10.1002/ijc.21507

Genes

ERBB4
EGFR
ERBB2
BRAF
ERBB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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