Article
Somatic mutations of the HER2 in metastatic breast cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2014
Fang Yi, Jiang Yanxia, Wang Xin, Yang Xue, Gao Yinqi, Wang Jing
Abstract excerpt
Mutations in the epidermal growth factor receptor gene (EGFR) in lung cancers predict for sensitivity to EGFR kinase inhibitors. HER2 (also known as NEU, EGFR2, or ERBB2) is a member of the EGFR family of receptor tyrosine kinases and plays important roles in the pathogenesis of certain human cancers, and mutations have recently been reported in lung cancers. We sequenced the full length of HER2 in 198 metastatic...
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