Article
Lung cancer: intragenic ERBB2 kinase mutations in tumours.
Nature - 30 Sept 2004
Stephens Philip, Hunter Chris, Bignell Graham, Edkins Sarah, Davies Helen, Teague Jon, Stevens Claire, O'Meara Sarah, Smith Raffaella, Parker Adrian, Barthorpe Andy, Blow Matthew, Brackenbury Lisa, Butler Adam, Clarke Oliver, Cole Jennifer, Dicks Ed, Dike Angus, Drozd Anja, Edwards Ken, Forbes Simon, Foster Rebecca, Gray Kristian, Greenman Chris, Halliday Kelly, Hills Katy, Kosmidou Vivienne, Lugg Richard, Menzies Andy, Perry Janet, Petty Robert, Raine Keiran, Ratford Lewis, Shepherd Rebecca, Small Alexandra, Stephens Yvonne, Tofts Calli, Varian Jennifer, West Sofie, Widaa Sara, Yates Andrew, Brasseur Francis, Cooper Colin S, Flanagan Adrienne M, Knowles Margaret, Leung Suet Y, Louis David N, Looijenga Leendert H J, Malkowicz Bruce, Pierotti Marco A, Teh Bin, Chenevix-Trench Georgia, Weber Barbara L, Yuen Siu T, Harris Grace, Goldstraw Peter, Nicholson Andrew G, Futreal P Andrew, Wooster Richard, Stratton Michael R
Abstract excerpt
The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies. We have sequenced the gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known...
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