Article
Antisense protein kinase A RI alpha-induced tumor reversion: portrait of a microarray.
Biochimica et biophysica acta - 11 Mar 2004
Cho-Chung Yoon S
Abstract excerpt
Antisense oligonucleotides can selectively block disease-causing genes due to the specificity of the Watson-Crick base-pairing mechanism of action. A genome-wide view of antisense technology is illustrated via protein kinase A RI alpha antisense. Complementary DNA microarray analysis of the RI alpha antisense-induced expression profile shows the up- and down-regulation of clusters of coordinately expressed genes...
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