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Article

Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene

1 Feb 2006

Abstract excerpt

Sirtuin 6 (SIRT6) is a member of the sirtuin deacetylases (sirtuins), which are derivatives of the yeast Silent information regulator 2 (Sir2) protein. SIR2 and its mammalian derivatives play a central role in epigenetic gene silencing, recombination, metabolism, cell differentiation and in the regulation of aging. In contrast to most sirtuins, SIRT6 lacks NAD+-dependent protein deacetylase activity. We have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16391800
DOI: 10.3892/ijo.28.2.447

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