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Article

Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1

1 Jan 2006

Abstract excerpt

Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (HDACs). The yeast Sir2 protein and its mammalian derivatives play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule organization, and in the regulation of aging. We have isolated...

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PMID: 16328012
DOI: 10.3892/ijmm.17.1.59

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